VIEW In Vitro & In Vivo STUDIES




In Vitro & In Vivo Published Research Sexual Health

1. Phenolic-rich extracts of Eurycoma longifolia and Cylicodiscus gabunensis inhibit enzymes  responsible for the development of erectile dysfunction and are antioxidants
J Basic Clin Physiol Pharmacol. 2018 Nov 27;29(6):689-696. Ganiyu Oboh, Adeniyi A Adebayo, Ayokunle O Ademosun

2. Brain Cortical and Hippocampal Dopamine: A New Mechanistic Approach for Eurycoma longifolia Well-Known Aphrodisiac Activity and Its Chemical Characterization
Evidence-Based Complementary and Alternative Medicine Volume 2019, Article ID 7543460. Shahira M. Ezzat, Marwa I. Ezzat, Mona M. Okba, Salah M. Hassan, Amgad I. Alkorashy, Mennatallah M. Karar,
Sherif H. Ahmed, and Shanaz O. Mohamed

3. Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the Management of Erectile Dysfunction
Evid Based Complement Alternat Med. 2019: 4341592. Shahira M. Ezzat, Mona M. Okba, Marwa I. Ezzat, Nora M. Aborehab, and Shanaz O. Mohamed

In Vitro & In Vivo Published Research Weight Loss

1. Antiadipogenic effects of a standardized quassinoids-enriched fraction and eurycomanone from Eurycoma longifolia
Phytothery Research. 2018 Jul;32(7):1332-1345. D Balan, Kit-Lam Chan, D Murugan, Sazaly A Bakar, Pooi-Fong Wong

2. Selection of Thai Medicinal Plants with Anti-Obesigenic Potential via in vitro method
Pharmaceuticals 2020, 13, 56; Wijitrapha Ruangaram 1 and Eisuke Kato

In Vitro & In Vivo Published Research Bone Health

1. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model
Evid Based Complement Alternat Med. 2012; 2012: 872406. Halimatun S.A Razak, Ahmad N Shuid, and Isa N Mohamed

2. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model
Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 818072 Abdul Shukor Tajul Ariff, Ima Nirwana Soelaiman, J. Pramanik, and Ahmad Nazrun Shuid

3. Eurycoma longifolia as a potential alternative to testosterone for the treatment of osteoporosis: Exploring time-mannered proliferative, differentiative and  morphogenic modulation in osteoblasts
J Ethnopharmacol . 2017 Jan 4;195:143-158. Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid

4. The Effects of Quassinoid-Rich Eurycoma longifolia Extract on Bone Turnover and Histomorphometry Indices in the Androgen-Deficient Osteoporosis Rat Model
Nutrients 2018, 10, 799; Putri Ayu Jayusman , Isa Naina Mohamed , Ekram Alias, Norazlina Mohamed and Ahmad Nazrun Shuid

5. An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models
Malays J Med Sci. 2018 Jul; 25(4): 6–30. Nur Adlina Mohammad, Norfarah Izzaty Razaly, Mohd Dzulkhairi Mohd Rani, Muhammad Shamsir Mohd Aris, Nadia Mohd Effendy

6. Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers
Journal of Ayurveda and Integrative Medicine 9 (2018) 272e280. Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid

7. Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation
Journal of Ayurveda and Integrative Medicine 10 (2019) 102e110. Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid

In Vitro & In Vivo Published Research Inflammation

1. Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation
Molecules 2014, 19, 14649-14666. Shéhérazade Hajjouli, Sébastien Chateauvieux, Marie-Hélène Teiten, Barbora Orlikova, Marc Schumacher, Mario Dicato, Chee-Yan Choo and Marc Diederich
2. NF-κB Inhibitors from Eurycoma longifolia
J Nat Prod. 2014 Mar 28; 77(3): 483–488. Thi Van Anh Tran, Clemens Malainer, Stefan Schwaiger, Atanas G. Atanasov, Elke H. Heiss, Verena M. Dirsch, and Hermann Stuppner
3. Anti-inflammatory and analgesic effects of Eurycoma longifolia extracts
Arch Pharm Res. 2016 Mar;39(3):421-8. Young Min Han, Sang-Uk Woo, Min Sun Choi, Yu Na Park, Seung Hyun Kim, Hyungshin Yim, Hye Hyun Yoo
4. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level
Journal of Natural Products. 2017, 80, 3186−3193. Clemens Malainer, Daniel Schachner, Enrico Sangiovanni, Atanas G. Atanasov, Stefan Schwaiger,
Hermann Stuppner, Elke H. Heiss, and Verena M. Dirsch
5. Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats
Evidence-Based Complementary and Alternative Medicine. Volume 2019, Article ID 4916519 Sasikala M. Chinnappan, Annie George, Praveen Thaggikuppe, YogendraKumar Choudhary, Vandana K. Choudhary, Yesha Ramani, and Rashmi Dewangan